FP Test is a method for diagnosing the stage of liver fibrosis and the degree of activity of chronic hepatitis according to the results of blood tests.
The method was developed in 2019 by employees of the experimental clinical research department of the Federal State Budgetary Institution “Research Institute of Influenza named after A.A. Smorodintseva" Ministry of Health of Russia.
The method is a machine learning model based on an artificial neural network that accepts the following clinical and laboratory parameters: gender, age, height and weight of the patient, as well as platelet count, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidases (GGT).
The test can be recommended for the diagnosis of liver damage in patients with chronic viral hepatitis C. The study should not be conducted in patients with acute hepatitis of any etiology, as well as in patients with chronic HCV infection during the period of exacerbation of the disease. Currently, other absolute contraindications for the study are not known. Relative contraindications that can distort the results of the study are other medical conditions that may be accompanied by thrombocytopenia.
The “gold standard” for diagnosing the stage of fibrosis, cirrhosis and the degree of activity of chronic hepatitis is a pathomorphological study of liver biopsy.
The accuracy of the method for the diagnosis of stage 3-4 liver fibrosis in comparison with a liver biopsy in patients with chronic HCV infection is 79% (sensitivity 70%, specificity 87%, PV + 84%, PV- 76%).
The accuracy of the method for diagnosing moderate or severe hepatitis activity compared with liver biopsy in patients with chronic HCV infection is 79% (sensitivity 78%, specificity 80%, PV + 82%, PV- 76%).
The results of the FP Test study are two calculated indices: the liver fibrosis index and the hepatitis activity index. The index is a number in the range from 0 to 1. An index value of more than 0.5 corresponds to a positive test result (the patient has stage 3-4 liver fibrosis or the patient has moderate or severe hepatitis activity). An index value of less than 0.5 corresponds to a negative test result (absence of stage 3-4 liver fibrosis in the patient or absence of moderate or severe hepatitis activity in the patient). The likelihood of getting the correct test answer depends on the index value. So the greater the 0.5 or less than 0.5 index value, the higher the likelihood of obtaining the correct positive or correct negative test result, respectively.
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